Understanding the endpoint

The multi-luminance mobility test (MLMT) course

The MLMT is a standardized, lab-based test that simulates everyday walking environments.1-3

Participants were observed while navigating a course with obstacles of varying height under different levels of illumination.1-3

Get a tour of the MLMT

  • After 40 minutes of dark adaptation, participants completed a configuration of the course with one eye patched, completed a new configuration with the other eye patched, and completed a third configuration using both eyes3
  • This process was repeated until failing and passing light-level thresholds were identified for each eye-patched condition, progessing from lower to higher prespecified light levels3
  • Participants were graded based on accuracy and speed3
    • Passing was defined as completion of the course at the specified lux level with fewer than 4 errors and within 3 minutes3

The MLMT has demonstrated construct and content validity and was specifically designed to measure the impact of LUXTURNA on activities of daily life1-3

Photographs are not of actual patients.

Varying levels of illumination

The 7 levels of illumination, referred to as lux levels, were chosen to represent lighting in everyday locations. To quantify study participant performance over time, an MLMT score change was calculated by assigning score codes to each lux level.1,2

Lux levels were measured using a standardized and calibrated light meter.1

The score change is the difference between the lowest lux level passed before treatment and after treatment.1,2