Additional endpoints

An impact on visual function results in functional improvement1-3

At Year 1, LUXTURNA® demonstrated statistically significant improvements in FST and VF and a nonstatistically significant improvement in VA4

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>100-fold improvement in light sensitivity4

A statistically significant difference in FST monocular averaged over both eyes of -2.11 log10(cd.s/m2) (95% CI: -3.19, -1.04) between groups4*†

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8-letter improvement in VA4

A nonstatistically significant difference in VA monocular averaged over both eyes of -0.16 LogMAR (95% CI: -0.41, 0.08) in the intervention group, compared with 0.01 LogMAR in the control group4*‡

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Nearly doubled VF in sum total degrees

A statistically significant difference of 378.7 sum total degrees between groups (95% CI: 145.5, 612.0)4*||

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Increased VF by nearly 8 dB4

A statistically significant difference in macula sensitivity thresholds of 7.9 dB between groups (95% CI: 3.5, 12.2)4*¶

LUXTURNA improved functional vision, which increased participants’ ability to perform activities of daily living2-4

*ITT population: intervention (n=21) vs control (n=10).4

P=0.0004.4 ‡P=0.17.4 §For the intervention group alone.4

||Post hoc P=0.0059, Goldmann test.4 Post hoc P=0.0005, Humphrey test.4

Photographs are not of actual patients.

"Rather than clinging to me when walking in dark areas, he now runs ahead on his own."

—MOTHER OF CHRIS, AGE 7

For illustrative purposes based on actual patient experience. Results will vary.5