Additional endpoints

An impact on visual function results in functional improvement1-3

At Year 1, LUXTURNA® demonstrated statistically significant improvements in FST and VF and a nonstatistically significant improvement in VA4

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>100-fold improvement in light sensitivity4

A statistically significant difference in FST monocular averaged over both eyes of -2.11 log10(cd.s/m2) (95% CI: -3.19, -1.04) between groups4*†

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8-letter improvement in VA4

A nonstatistically significant difference in VA monocular averaged over both eyes of -0.16 LogMAR (95% CI: -0.41, 0.08) in the intervention group, compared with 0.01 LogMAR in the control group4*‡

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Nearly doubled VF in sum total degrees

A statistically significant difference of 378.7 sum total degrees between groups (95% CI: 145.5, 612.0)4*||

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Increased VF by nearly 8 dB4

A statistically significant difference in macula sensitivity thresholds of 7.9 dB between groups (95% CI: 3.5, 12.2)4*¶

LUXTURNA improved functional vision, which increased participants’ ability to perform activities of daily living2-4

*ITT population: intervention (n=21) vs control (n=10).4

P=0.0004.4 ‡P=0.17.4 §For the intervention group alone.4

||Post hoc P=0.0059, Goldmann test.4 Post hoc P=0.0005, Humphrey test.4

Photographs are not of actual patients.

"Rather than clinging to me when walking in dark areas, he now runs ahead on his own."


For illustrative purposes based on actual patient experience. Results will vary.5