The multi-luminance mobility test (MLMT) results

LUXTURNA® improved functional vision

At Year 1, participants treated with LUXTURNA demonstrated a statistically significant and clinically meaningful improvement in their ability to navigate at lower lux levels.1*

Efficacy Outcomes LUXTURNA
n=21
Control
n=10
Difference
(LUXTURNA - Control)
P-value
MLMT score change for bilateral eyes, median (min, max) 2 (0, 4) 0 (-1, 2) 2 0.001
MLMT score change for first-treated eye, median (min, max) 2 (0, 4) 0 (-1, 1) 2 0.003

Watch how LUXTURNA improved functional vision

Representative of clinical trial participants with clinically meaningful score change of 2 from baseline1-3

Baseline visit at 1 lux (FAIL)

1-year visit after LUXTURNA administration at 1 lux (PASS)

The camera used automatically adjusts the level and temperature of light that it captures. Because of this feature, there may be slight variations in hue when filming at low light levels (eg, 1 lux). Both videos were filmed in low‑light environments.

Note: This participant’s baseline passing level was 10 lux and 1-year passing level was 1 lux.

55% of all participants had an MLMT score change of 2 or greater (16 out of 29)2*

%

65% of participants (13 of 20) in the intervention group successfully completed the MLMT at the lowest light level of 1 lux, while no participants in the control group passed at this level 1 year posttreatment4

%

89% of participants (8 of 9) who subsequently crossed over passed at 1 lux 1 year posttreatment2

LUXTURNA has demonstrated sustained efficacy

Improvements in functional vision have been sustained for 4 years—with observations ongoing. Follow-up will continue for up to 15 years postadministration.5-7

*ITT population intervention (n=21) vs control (n=10).1

Photographs are not of actual patients.

"This year, he was able to walk on stage by himself for the first time. His teacher no longer has to lead him to his place."

—FATHER OF STEVE, AGE 15

For illustrative purposes based on actual patient experience. Results will vary.2